Article
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase and breast cancer chemotherapy response.
Genetics and molecular research : GMR - 23 Sept 2016
Yang L, Wang X W, Zhu L P, Wang H L, Wang B, Wu T, Zhao Q, JinSiHan D L X T, Wang X Y
Abstract excerpt
Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Due to such polymorphisms, individuals differ in MTHFR enzyme activity and plasma folate levels. We inve...
Topics
- Adult
- Aged
- Breast Neoplasms
- Female
- Genetic Predisposition to Disease
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Polymorphism, Genetic
- Treatment Outcome