Article
The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI).
International journal of molecular sciences - 7 Apr 2021
Elefanti Lisa, Zamuner Carolina, Del Fiore Paolo, Stagni Camilla, Pellegrini Stefania, Dall'Olmo Luigi, Fabozzi Alessio, Senetta Rebecca, Ribero Simone, Salmaso Roberto, Mocellin Simone, Bassetto Franco, Cavallin Francesco, Tosi Anna Lisa, Galuppini Francesca, Dei Tos Angelo Paolo, Menin Chiara, Cappellesso Rocco
Abstract excerpt
Acral melanoma (AM) is a rare and aggressive subtype of melanoma affecting the palms, soles, and nail apparatus with similar incidence among different ethnicities. AM is unrelated to ultraviolet radiation and has a low mutation burden but frequent chromosomal rearrangements and gene amplifications. Next generation sequencing of 33 genes and somatic copy number variation (CNV) analysis with genome-wide single...
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