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Article

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.

Cell reports - 30 Jun 2020

Renoux Florian, Stellato Mara, Haftmann Claudia, Vogetseder Alexander, Huang Riyun, Subramaniam Arun, Becker Mike O, Blyszczuk Przemyslaw, Becher Burkhard, Distler Jörg H W, Kania Gabriela, Boyman Onur, Distler Oliver

Abstract excerpt

Regulatory T cells (Tregs) represent a major population in the control of immune homeostasis and autoimmunity. Here we show that Fos-like 2 (Fosl2), a TCR-induced AP1 transcription factor, represses Treg development and controls autoimmunity. Mice overexpressing Fosl2 (Fosl2tg) indeed show a systemic inflammatory phenotype, with immune infiltrates in multiple organs. This phenotype is absent in Fosl2tg × Rag2-/-...

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Source

Identifiers

PMID: 32610127
DOI: 10.1016/j.celrep.2020.107826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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