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Article

LAT regulates gammadelta T cell homeostasis and differentiation.

Nature immunology - 1 Oct 2003

Nuñez-Cruz Selene, Aguado Enrique, Richelme Sylvie, Chetaille Bruno, Mura Anne-Marie, Richelme Mireille, Pouyet Laurent, Jouvin-Marche Evelyne, Xerri Luc, Malissen Bernard, Malissen Marie

Abstract excerpt

LAT (linker for activation of T cells) is essential for T cell receptor signaling. Mice homozygous for a mutation of the three C-terminal LAT tyrosine residues showed a block in alphabeta T cell development and a partially impaired gammadelta T cell development. Without intentional immunization,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, gamma-delta

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Source

Identifiers

PMID: 12970761
DOI: 10.1038/ni977

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12970761-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

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Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function.Semantic proximity Read ↗

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.Semantic proximity Read ↗

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