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Article

Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction

29 Apr 2021

Abstract excerpt

Background: Genetic variants in SCN10A , encoding the neuronal voltage-gated sodium channel Na V 1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac conduction velocities, and heart rate. The cardiac function of SCN10A has not been resolved, however, and diverging mechanisms have been proposed. Here, we investigated the cardiac expression of SCN10A and the function of a...

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PMID: 33910361
DOI: 10.1161/circulationaha.121.054083

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