Article

Gene-Gene Interactions Between A<i>LMNA</i>Variant and Common Polymorphisms Drive Early-Onset Atrial Fibrillation

2025-05-05

Abstract excerpt

Atrial fibrillation (AF) is a common arrhythmia with a complex genetic basis, yet the molecular mechanisms linking rare and common variants remain unclear. Using induced pluripotent stem cell-derived atrial cardiomyocytes, we uncover a novel mechanism by which a rare pathogenic LMNA variant encoding Lamin A/C disrupts chromatin accessibility and gene regulation at AF-associated loci. Specifically, reduced accessib...

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Literature Corpus work: a8e8a047-1452-5a2f-9f34-22c816c8447c
DOI: 10.1101/2025.05.05.25326834

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