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Article

SCN10A-short gene therapy to restore conduction and protect against malignant cardiac arrhythmias

20 Feb 2025

Abstract excerpt

BACKGROUND AND AIMS: Life-threatening arrhythmias are a well-established consequence of reduced cardiac sodium current (INa). Gene therapy approaches to increase INa have demonstrated potential benefits to prevent arrhythmias. However, the development of such therapies is hampered by the large size of sodium channels. In this study, SCN10A-short (S10s), a short transcript encoding the carboxy-terminal domain of...

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PMID: 39973098
DOI: 10.1093/eurheartj/ehaf053

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