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Article

Nav-igating through a complex landscape: SCN10A and cardiac conduction.

The Journal of clinical investigation - 1 Apr 2014

Park David S, Fishman Glenn I

Abstract excerpt

Genome-wide association studies (GWAS) have implicated SCN10A, which encodes a nociceptor-associated voltage-gated sodium channel subunit, as a modulator of cardiac conduction; however, this role has traditionally been ascribed to SCN5A, which is highly expressed in cardiac muscle. SCN10A is believed to affect cardiac conduction either directly through cardiomyocytes or indirectly via intracardiac neurons. In...

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Identifiers

PMID: 24642462
DOI: 10.1172/JCI75240
PMCID: PMC3973102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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