Genetic variation in SCN10A influences cardiac conduction.

doi:10.1038/ng.516

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Article

Genetic variation in SCN10A influences cardiac conduction.

Nature genetics - 1 Feb 2010

Chambers John C, Zhao Jing, Terracciano Cesare M N, Bezzina Connie R, Zhang Weihua, Kaba Riyaz, Navaratnarajah Manoraj, Lotlikar Amol, Sehmi Joban S, Kooner Manraj K, Deng Guohong, Siedlecka Urszula, Parasramka Saurabh, El-Hamamsy Ismail, Wass Mark N, Dekker Lukas R C, de Jong Jonas S S G, Sternberg Michael J E, McKenna William, Severs Nicholas J, de Silva Ranil, Wilde Arthur A M, Anand Praveen, Yacoub Magdi, Scott James, Elliott Paul, Wood John N, Kooner Jaspal S

Abstract excerpt

To identify genetic factors influencing cardiac conduction, we carried out a genome-wide association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified association of a nonsynonymous SNP, rs6795970, in SCN10A (P = 2.8 x 10(-15)) with PR interval, a marker of cardiac atrioventricular conduction. Replication testing among 6,243 Indian Asians and 5,370 Europeans confirmed that...

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PMID: 20062061
DOI: 10.1038/ng.516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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