Article
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.
The Journal of clinical investigation - 1 Jul 2012
van den Boogaard Malou, Wong L Y Elaine, Tessadori Federico, Bakker Martijn L, Dreizehnter Lisa K, Wakker Vincent, Bezzina Connie R, 't Hoen Peter A C, Bakkers Jeroen, Barnett Phil, Christoffels Vincent M
Abstract excerpt
The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous gene expression by key transcription factors and transcriptional enhancers. Here, we assessed the genome-wide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.