Article

Novel protein-altering variants associated with serum apolipoprotein and lipid levels

2021-09-23

Abstract excerpt

Dyslipidemia is a major risk factor for cardiovascular disease. While common genetic variants are known to modestly affect the serum lipid concentrations, rare genetic mutations can cause monogenic forms of hypercholesteremia and other genetic disorders of lipid metabolism. Aiming to identify low-frequency protein-altering variants (PAVs) affecting lipoprotein and lipid traits, we analyzed whole-exome and whole-ge...

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Literature Corpus work: 8cac0a32-d173-5032-ae5a-040952c98238
DOI: 10.1101/2021.09.19.21263610

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