Article
Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank.
Diabetes - 1 Oct 2020
Klimentidis Yann C, Arora Amit, Newell Michelle, Zhou Jin, Ordovas Jose M, Renquist Benjamin J, Wood Alexis C
Abstract excerpt
Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to more comprehensively examine the phenotypic and genotypic relationships of LDL-C with T2D. Using data from the UK Biobank, we found that levels of circulating LDL-C...
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