Article
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Scientific reports - 16 May 2016
Valentin-Vega Yasmine A, Wang Yong-Dong, Parker Matthew, Patmore Deanna M, Kanagaraj Anderson, Moore Jennifer, Rusch Michael, Finkelstein David, Ellison David W, Gilbertson Richard J, Zhang Jinghui, Kim Hong Joo, Taylor J Paul
Abstract excerpt
DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported recurrent DDX3X mutations in numerous tumors including medulloblastoma (MB), but the physiological impact of these mutations is poorly understood. Here we show that a consistent feature of MB-associated...
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