Article
The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.
Cells - 20 Sept 2022
Balcerak Anna, Macech-Klicka Ewelina, Wakula Maciej, Tomecki Rafal, Goryca Krzysztof, Rydzanicz Malgorzata, Chmielarczyk Mateusz, Szostakowska-Rodzos Malgorzata, Wisniewska Marta, Lyczek Filip, Helwak Aleksandra, Tollervey David, Kudla Grzegorz, Grzybowska Ewa A
Abstract excerpt
HAX1 is a human protein with no known homologues or structural domains. Mutations in the HAX1 gene cause severe congenital neutropenia through mechanisms that are poorly understood. Previous studies reported the RNA-binding capacity of HAX1, but the role of this binding in physiology and pathology remains unexplained. Here, we report the transcriptome-wide characterization of HAX1 RNA targets using RIP-seq and...
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