Article
Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum.
Nature communications - 2 Jun 2026
Perry T A, Deng Y, Hulley P A, Maciewicz R A, Mitchelmore J, Larsson S, Gogain J, Brachat S, Struglics A, Appleton C T, Kluzek S, Arden N K, Felson D, Bondi L, Kapoor M, Lohmander L S, Welting T J, Walsh D A, Valdes A M, Jostins-Dean Luke, Watt Fiona E, Tom B D M, Vincent T L
Abstract excerpt
Knee osteoarthritis affects 40% of people during their lifetime, significantly impacting societies worldwide. Its molecular pathogenesis remains poorly understood and variable clinical phenotypes suggest it may be more than one disease. We established Synovial fluid To detect Endotypes by Unbiased Proteomics in OA (STEpUP OA) to search for molecular endotypes in knee OA synovial fluid, and to reveal key...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.