Article
Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage
22 Dec 2017
Abstract excerpt
INTRODUCTION: Osteoarthritis (OA) is a heterogeneous and complex disease. We have used a network biology approach based on genome-wide analysis of gene expression in OA knee cartilage to seek evidence for pathogenic mechanisms that may distinguish different patient subgroups. METHODS: Results from RNA-Sequencing (RNA-Seq) were collected from intact knee cartilage at total knee replacement from 44 patients with...
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