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Article

PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia.

Genes & development - 1 Jun 2018

Liu Wenying Angela, Chen She, Li Zhizhong, Lee Choong Heon, Mirzaa Ghayda, Dobyns William B, Ross M Elizabeth, Zhang Jiangyang, Shi Song-Hai

Abstract excerpt

Proper organization and orderly mitosis of radial glial progenitors (RGPs) drive the formation of a laminated mammalian cortex in the correct size. However, the molecular underpinnings of the intricate process remain largely unclear. Here we show that RGP behavior and cortical development are controlled by temporally distinct actions of partitioning-defective 3 (PARD3) in concert with dynamic HIPPO signaling....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29899142
DOI: 10.1101/gad.313171.118
PMCID: PMC6049519

Genes

PARD3

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