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Article

Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors.

Nature communications - 16 Nov 2016

Damiani Devid, Goffinet André M, Alberts Arthur, Tissir Fadel

Abstract excerpt

The diaphanous homologue Diaph3 (aka mDia2) is a major regulator of actin cytoskeleton. Loss of Diaph3 has been constantly associated with cytokinesis failure ascribed to impaired accumulation of actin in the cleavage furrow. Here we report that Diaph3 is required before cell fission, to ensure the accurate segregation of chromosomes. Inactivation of the Diaph3 gene causes a massive loss of cortical progenitor...

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Identifiers

PMID: 27848932
DOI: 10.1038/ncomms13509
PMCID: PMC5476800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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