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In vitro differentiation of human pluripotent stem cells into the B lineage using OP9-MS5 co-culture

1 Apr 2021

Abstract excerpt

In vitro differentiation of human pluripotent stem cells (hPSCs) offers a genetically tractable system to examine the physiology and pathology of human tissue development and differentiation. We have used this approach to model the earliest stages of human B lineage development and characterize potential target cells for the in utero initiation of childhood B acute lymphoblastic leukemia. Herein, we detail...

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PMID: 33899010
DOI: 10.1016/j.xpro.2021.100420

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