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Generation of complex bone marrow organoids from human induced pluripotent stem cells

19 Feb 2024

Abstract excerpt

The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a method for generating complex BM-like organoids (BMOs) from human induced pluripotent stem cells (iPSCs). BMOs consist of key cell types that self-organize into spatially defined three-dimensional structures mimicking cellular, structural and molecular characteristics of the hematopoietic microenvironment. Functional properties...

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PMID: 38374263
DOI: 10.1038/s41592-024-02172-2

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