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Article

Toward a better definition of hematopoietic progenitors suitable for B cell differentiation.

PloS one - 1 Jan 2020

Dubois Florian, Gaignerie Anne, Flippe Léa, Heslan Jean-Marie, Tesson Laurent, Chesneau Mélanie, Haspot Fabienne, Conchon Sophie, David Laurent, Brouard Sophie

Abstract excerpt

The success of inducing human pluripotent stem cells (hIPSC) offers new opportunities for cell-based therapy. Since B cells exert roles as effector and as regulator of immune responses in different clinical settings, we were interested in generating B cells from hIPSC. We differentiated human embryonic stem cells (hESC) and hIPSC into B cells onto OP9 and MS-5 stromal cells successively. We overcame issues in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33320872
DOI: 10.1371/journal.pone.0243769
PMCID: PMC7737978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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