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Article

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.

Journal of neurochemistry - 1 Oct 2011

Rabe Sabine, Reichwald Julia, Ammaturo Domenico, de Strooper Bart, Saftig Paul, Neumann Ulf, Staufenbiel Matthias

Abstract excerpt

Inhibition of β-secretase (BACE1) is a key therapeutic approach in Alzheimer's disease (AD), as BACE1 initiates amyloid-β (Aβ) cleavage from the β-amyloid precursor protein (APP). As Aβ reductions in mice lacking one BACE1 allele diverged considerably between studies we investigated the effect of BACE1 knock-out in more detail. With both BACE1 alleles the Swedish mutation (APP23 mice) increased APP processing and...

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Source

Identifiers

PMID: 21812781
DOI: 10.1111/j.1471-4159.2011.07412.x

Genes

BACE1
APP

Provenance

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