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Article

Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease.

Discovery medicine - 1 Sept 2012

Zhang Can

Abstract excerpt

Alzheimer's disease (AD) is a fatal neurodegenerative disorder and the primary cause of dementia, with no cure presently available. The pathogenesis of AD is believed to be primarily driven by amyloid-β (Aβ), the principal component of senile plaques in the AD brain. Aβ is generated through a sequential proteolytic process initiated by BACE1, or β-secretase, from the amyloid-β precursor protein (APP)....

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 23021373

Genes

BACE1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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