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Article

Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease

22 Apr 2021

Abstract excerpt

OBJECTIVE: To evaluate upstream and downstream regulators leading to macrophage activation and subsequent cytokine storm in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-associated interstitial lung disease (ILD). METHODS: We conducted an integrated miRNA-mRNA association analysis using circulating monocytes from 3 patients with anti-MDA5-associated ILD and 3 healthy controls and...

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Share to Inflammatory Myopathies and Dermatomyositis
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PMID: 33890985
DOI: 10.1093/rheumatology/keab371

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