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Article

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression.

Nature neuroscience - 1 Mar 2015

Chung Woosuk, Choi Su Yeon, Lee Eunee, Park Haram, Kang Jaeseung, Park Hanwool, Choi Yeonsoo, Lee Dongsoo, Park Sae-Geun, Kim Ryunhee, Cho Yi Sul, Choi Jeonghoon, Kim Myoung-Hwan, Lee Jong Won, Lee Seungjoon, Rhim Issac, Jung Min Whan, Kim Daesoo, Bae Yong Chul, Kim Eunjoon

Abstract excerpt

Social deficits are observed in diverse psychiatric disorders, including autism spectrum disorders and schizophrenia. We found that mice lacking the excitatory synaptic signaling scaffold IRSp53 (also known as BAIAP2) showed impaired social interaction and communication. Treatment of IRSp53(-/-)...

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Source

Identifiers

PMID: 25622145
DOI: 10.1038/nn.3927

Genes

BAIAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25622145-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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