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Article

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency.

Molecular psychiatry - 1 Sept 2020

Bacq Alexandre, Astori Simone, Gebara Elias, Tang Wei, Silva Bianca A, Sanchez-Mut Jose, Grosse Jocelyn, Guillot de Suduiraut Isabelle, Zanoletti Olivia, Maclachlan Catherine, Knott Graham W, Gräff Johannes, Sandi Carmen

Abstract excerpt

Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying mechanisms, effective treatments for abnormal aggression are still missing. Recently, genetic variations in Sialyltransferase 2 (St8sia2) have been linked to these disorders and aggression. Here we identify abnormal aggressive behaviors...

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Identifiers

PMID: 30089788
DOI: 10.1038/s41380-018-0132-3
PMCID: PMC7473847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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