Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

doi:10.1093/eurheartj/eht447

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Article

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.

European heart journal - 1 Feb 2014

Seppälä Ilkka, Kleber Marcus E, Lyytikäinen Leo-Pekka, Hernesniemi Jussi A, Mäkelä Kari-Matti, Oksala Niku, Laaksonen Reijo, Pilz Stefan, Tomaschitz Andreas, Silbernagel Günther, Boehm Bernhard O, Grammer Tanja B, Koskinen Tuomas, Juonala Markus, Hutri-Kähönen Nina, Alfthan Georg, Viikari Jorma S A, Kähonen Mika, Raitakari Olli T, März Winfried, Meinitzer Andreas, Lehtimäki Terho

Abstract excerpt

AIMS: The purpose of this study was to identify novel genetic variants influencing circulating asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels and to evaluate whether they have a prognostic value on cardiovascular mortality. METHODS AND RESULTS: We conducted a genome-wide association study on the methylarginine traits and investigated the predictive value of the new discovered...

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Identifiers

PMID: 24159190
DOI: 10.1093/eurheartj/eht447

Genes

AGXT2
DDAH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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