Article
CanDriS: posterior profiling of cancer-driving sites based on two-component evolutionary model.
Briefings in bioinformatics - 2 Sept 2021
Zhao Wenyi, Yang Jingwen, Wu Jingcheng, Cai Guoxing, Zhang Yao, Haltom Jeffrey, Su Weijia, Dong Michael J, Chen Shuqing, Wu Jian, Zhou Zhan, Gu Xun
Abstract excerpt
Current cancer genomics databases have accumulated millions of somatic mutations that remain to be further explored. Due to the over-excess mutations unrelated to cancer, the great challenge is to identify somatic mutations that are cancer-driven. Under the notion that carcinogenesis is a form of somatic-cell evolution, we developed a two-component mixture model: while the ground component corresponds to...
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