Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

International journal of molecular sciences - 16 Aug 2021

Arrigo Angelo B, Lin Jiuann-Huey Ivy

Abstract excerpt

Endocytic trafficking is an under-appreciated pathway in cardiac development. Several genes related to endocytic trafficking have been uncovered in a mutagenic ENU screen, in which mutations led to congenital heart defects (CHDs). In this article, we review the relationship between these genes (including LRP1 and LRP2) and cardiac neural crest cells (CNCCs) during cardiac development. Mice with an ENU-induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Disease Models, Animal
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylnitrosourea

Share to Heart Defects, Congenital

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Low Density Lipoprotein Receptor-Related Protein-2

Share to Neural Crest

Source

Open in PubMed Open full text

Identifiers

PMID: 34445520
DOI: 10.3390/ijms22168816
PMCID: PMC8396181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.PMID 34445520Read ↗

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read ↗

<i>Fgf8</i>is required for pharyngeal arch and cardiovascular development in the mouseSemantic proximity Read ↗

Genetic and Cellular Interaction During Cardiovascular Development Implicated in Congenital Heart DiseasesSemantic proximity Read ↗

Altered Cardiac Neural Crest Migration Patterning in a Left Atrial Ligation Model of Hypoplastic Left Heart SyndromeSemantic proximity Read ↗

Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progressionSemantic proximity Read ↗

N-Myc downstream regulated gene 1b is a regulator of cell adhesion during early muscle developmentSemantic proximity Read ↗

TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and humanSemantic proximity Read ↗

Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during embryonic and neonatal developmentSemantic proximity Read ↗

Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures.Semantic proximity Read ↗

Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.Semantic proximity Read ↗

Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects.Semantic proximity Read ↗

The genetic landscape of cardiovascular left-right patterning defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.