Article

A Ubiquitin network safeguards cell identity by continuously degrading a stem-cell related translational machinery

2026-03-08

Abstract excerpt

<h4>Summary</h4> How cell identity is maintained is a fundamental question, and loss of cell identity is a hallmark of aging that is associated with multiple age-related diseases. In the adult Drosophila midgut, we identified a post-transcriptional regulatory layer that supervises enterocyte (EC) identity and fails upon aging. Combining single-cell RNA-seq with lineage tracing in aging ECs and classical genetics...

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Literature Corpus work: 64c34f1b-1a94-502b-9956-21d60acb8b05
DOI: 10.64898/2026.03.06.709266

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