Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein tyrosine phosphatases in autoimmunity.

Annual review of immunology - 1 Jan 2008

Vang Torkel, Miletic Ana V, Arimura Yutaka, Tautz Lutz, Rickert Robert C, Mustelin Tomas

Abstract excerpt

Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant of the lymphoid tyrosine phosphatase (PTPN22), which is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PTPN22 gene
Share to Leukocyte Common Antigens
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmunity

Share to Polymorphism, Single Nucleotide

Share to Protein Kinase Inhibitors

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Protein Tyrosine Phosphatases

Source

Identifiers

PMID: 18303998
DOI: 10.1146/annurev.immunol.26.021607.090418

Genes

PTPN22
PTPRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein tyrosine phosphatases in autoimmunity.PMID 18303998Read ↗

The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.Semantic proximity Read ↗

Protein tyrosine phosphatase PTPN22 in human autoimmunity.Semantic proximity Read ↗

Lymphoid-specific tyrosine phosphatase (Lyp): a potential drug target for treatment of autoimmune diseases.Semantic proximity Read ↗

PTPN22: the archetypal non-HLA autoimmunity gene.Semantic proximity Read ↗

Regulation of T Cell Signaling and Immune Responses by PTPN22.Semantic proximity Read ↗

Role of PTPN22 in type 1 diabetes and other autoimmune diseases.Semantic proximity Read ↗

The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity.Semantic proximity Read ↗

Genetic Polymorphism of PTPN22 in Autoimmune Diseases: A Comprehensive Review.Semantic proximity Read ↗

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Semantic proximity Read ↗

Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.Semantic proximity Read ↗

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?Semantic proximity Read ↗

The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.