Article
Brief Report: Common Genetic Variation in Chromosome 10 q22.1 Shows a Strong Sex Bias in Human Embryonic Stem Cell Lines and Directly Controls the Novel Alternative Splicing of Human NODAL which is Associated with XIST Expression in Female Cell Lines.
Stem cells (Dayton, Ohio) - 1 Mar 2016
Findlay Scott D, Postovit Lynne-Marie
Abstract excerpt
The potential use of pluripotent stem cells for personalized regenerative medicine necessitates an improved understanding of how germ-line genetic variation may affect pluripotency. Given previous reports of a female bias in established human embryonic stem cell (hESC) lines, sex-specific differences must also be considered. Herein we describe, for the first time, how genetic polymorphisms may affect the...
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