TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia.

doi:10.1158/2643-3230.BCD-20-0029

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Article

TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia.

Blood cancer discovery - 1 Mar 2021

Yun Seongseok, Vincelette Nicole D, Yu Xiaoqing, Watson Gregory W, Fernandez Mario R, Yang Chunying, Hitosugi Taro, Cheng Chia-Ho, Freischel Audrey R, Zhang Ling, Li Weimin, Hou Hsinan, Schaub Franz X, Vedder Alexis R, Cen Ling, McGraw Kathy L, Moon Jungwon, Murphy Daniel J, Ballabio Andrea, Kaufmann Scott H, Berglund Anders E, Cleveland John L

Abstract excerpt

MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism and tumorigenesis. A variety of alterations drive MYC expression in acute myeloid leukemia (AML) and enforced MYC expression in hematopoietic progenitors is sufficient to induce AML. Here we report that AML and myeloid progenitor cell growth and survival rely on MYC-directed suppression of Transcription Factor EB (TFEB), a...

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Identifiers

PMID: 33860275
DOI: 10.1158/2643-3230.BCD-20-0029
PMCID: PMC8043621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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