Article
MYC overexpression is associated with an early disease progression from MDS to AML.
Leukemia research - 1 Dec 2021
Gajzer David, Logothetis Constantine N, Sallman David A, Calon Gregoire, Babu Abida, Chan Onyee, Vincelette Nicole D, Volpe Virginia O, Al Ali Najla H, Basra Pukhraz, Talati Chetasi, Kuykendall Andrew T, Mo Qianxing, Padron Eric, Sweet Kendra, Komrokji Rami S, Lancet Jeffrey E, Yun Seongseok, Zhang Ling
Abstract excerpt
Recent studies demonstrated that MYC epigenetically regulates AML cell survival and differentiation by suppressing IDH1/2-TET2-5hmC signaling and that MYC overexpression is associated with poor survival outcomes in multiple AML patient cohorts. However, the oncogenic roles of MYC in MDS remain to be explored. A total of 41 patients with de novo MDS were retrospectively identified using the Total Cancer Care...
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