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Article

Roles of IDH1/2 and TET2 mutations in myeloid disorders.

International journal of hematology - 1 Jun 2016

Inoue Satoshi, Lemonnier François, Mak Tak W

Abstract excerpt

Mutations of the epigenetic enzymes isocitrate dehydrogenase (IDH) 1 and 2, and the methylcytosine dioxygenase 'ten-eleven translocation 2' (TET2), are common in human myeloid malignancies and drivers of these disorders but the underlying mechanisms remain obscure. This review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26980223
DOI: 10.1007/s12185-016-1973-7

Genes

TET2
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Roles of IDH1/2 and TET2 mutations in myeloid disorders.PMID 26980223Read ↗

TET2 mutation as prototypic clonal hematopoiesis lesion.Semantic proximity Read ↗

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IDH2 mutations in acute myeloid leukemia.Semantic proximity Read ↗

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.Semantic proximity Read ↗

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Semantic proximity Read ↗

Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.Semantic proximity Read ↗

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases.Semantic proximity Read ↗

IDH1/2 mutations in acute myeloid leukemiaSemantic proximity Read ↗

Genetic Polymorphism Study of IDH 1/2 and TET2 Genes in Acute Myeloid leukemia Patients.Semantic proximity Read ↗

TET2 as an epigenetic master regulator for normal and malignant hematopoiesis.Semantic proximity Read ↗

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis.Semantic proximity Read ↗

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