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Article

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.

Nature communications - 1 Jan 2013

Guilhamon Paul, Eskandarpour Malihe, Halai Dina, Wilson Gareth A, Feber Andrew, Teschendorff Andrew E, Gomez Valenti, Hergovich Alexander, Tirabosco Roberto, Fernanda Amary M, Baumhoer Daniel, Jundt Gernot, Ross Mark T, Flanagan Adrienne M, Beck Stephan

Abstract excerpt

Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and chondrosarcoma (CS). For AML, low-grade glioma and CC, mutant IDH status is associated with a DNA hypermethylation phenotype, implicating altered epigenome dynamics in the aetiology of these cancers. Here we show that the IDH variants in CS are also associated with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23863747
DOI: 10.1038/ncomms3166
PMCID: PMC3759038

Genes

EBF1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.PMID 23863747Read ↗

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