UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.

doi:10.1038/s41375-023-01906-z

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Article

UBTF tandem duplications define a distinct subtype of adult de novo acute myeloid leukemia.

Leukemia - 1 Jun 2023

Duployez Nicolas, Vasseur Loïc, Kim Rathana, Largeaud Laëtitia, Passet Marie, L'Haridon Anaïs, Lemaire Pierre, Fenwarth Laurène, Geffroy Sandrine, Helevaut Nathalie, Celli-Lebras Karine, Adès Lionel, Lebon Delphine, Berthon Céline, Marceau-Renaut Alice, Cheok Meyling, Lambert Juliette, Récher Christian, Raffoux Emmanuel, Micol Jean-Baptiste, Pigneux Arnaud, Gardin Claude, Delabesse Eric, Soulier Jean, Hunault Mathilde, Dombret Hervé, Itzykson Raphael, Clappier Emmanuelle, Preudhomme Claude

Abstract excerpt

Tandem duplications (TDs) of the UBTF gene have been recently described as a recurrent alteration in pediatric acute myeloid leukemia (AML). Here, by screening 1946 newly diagnosed adult AML, we found that UBTF-TDs occur in about 3% of patients aged 18-60 years, in a mutually exclusive pattern with other known AML subtype-defining alterations. The characteristics of 59 adults with UBTF-TD AML included young age...

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PMID: 37085611
DOI: 10.1038/s41375-023-01906-z
PMCID: PMC10244165

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