Article
RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy.
International journal of molecular sciences - 27 Sept 2022
Romanova Ekaterina I, Zubritskiy Anatoliy V, Lioznova Anna V, Ogunleye Adewale J, Golotin Vasily A, Guts Anna A, Lennartsson Andreas, Demidov Oleg N, Medvedeva Yulia A
Abstract excerpt
Acute myeloid leukemia (AML) is a rapidly progressing heterogeneous disease with a high mortality rate, which is characterized by hyperproliferation of atypical immature myeloid cells. The number of AML patients is expected to increase in the near future, due to the old-age-associated nature of AML and increased longevity in the human population. RUNX1 and CEBPA, key transcription factors (TFs) of hematopoiesis,...
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