Generation of human appetite-regulating neurons and tanycytes from stem cells

Abstract excerpt

<title>Abstract</title> <p>The balance between energy intake and expenditure is controlled by the hypothalamus, a small brain region characterised by high neuronal diversity. Specifically, the arcuate nucleus (ARC) and ventromedial hypothalamus (VMH) are key hypothalamic nuclei controlling appetite through behavioural response to circulating humoral signals. Yet, despite their physiological importance, the cellul...

Topics

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• Adipose Tissue and Metabolism
• Genetics and Neurodevelopmental Disorders
• Growth Hormone and Insulin-like Growth Factors
• Hypothalamic control of reproductive hormones
• Pancreatic function and diabetes
• Regulation of Appetite and Obesity
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

5fcc6812-db2a-53d3-84e7-ddd493abb067

DOI

10.21203/rs.3.rs-4719097/v1