Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

21 Mar 2019

Abstract excerpt

Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is necessary for prenatal growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Syndromes and Imprinting
Share to Growth Hormone and Insulin-like Growth Factors
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30905741
DOI: 10.1016/j.stemcr.2019.02.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and IntestinePMID 30905741Read ↗

Expanding the Mind: Insulin-Like Growth Factor I and Brain DevelopmentSemantic proximity Read ↗

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood.Semantic proximity Read ↗

Subventricular zone adult mouse neural stem cells and human glioblastoma stem cells require insulin receptor for self-renewalSemantic proximity Read ↗

Insulin-Like Growth Factor 2 As a Possible Neuroprotective Agent and Memory Enhancer—Its Comparative Expression, Processing and Signaling in Mammalian CNSSemantic proximity Read ↗

Neural precursor cells contribute to decision-making by tuning striatal connectivity via secretion of IGFBPL-1Semantic proximity Read ↗

Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine SystemSemantic proximity Read ↗

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.Semantic proximity Read ↗

Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology.Semantic proximity Read ↗

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in miceSemantic proximity Read ↗

Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response.Semantic proximity Read ↗

Spatially Organized IGF1-mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational ProgramsSemantic proximity Read ↗

Molecular basis of the little mouse phenotype and implications for cell type-specific growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.