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Article

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2010

Ragvin Anja, Moro Enrico, Fredman David, Navratilova Pavla, Drivenes Øyvind, Engström Pär G, Alonso M Eva, de la Calle Mustienes Elisa, Gómez Skarmeta José Luis, Tavares Maria J, Casares Fernando, Manzanares Miguel, van Heyningen Veronica, Molven Anders, Njølstad Pål R, Argenton Francesco, Lenhard Boris, Becker Thomas S

Abstract excerpt

Genome-wide association studies identified noncoding SNPs associated with type 2 diabetes and obesity in linkage disequilibrium (LD) blocks encompassing HHEX-IDE and introns of CDKAL1 and FTO [Sladek R, et al. (2007) Nature 445:881-885; Steinthorsdottir V, et al. (2007) Nat. Genet 39:770-775; Fra...

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Identifiers

PMID: 20080751
DOI: 10.1073/pnas.0911591107
PMCID: PMC2818943

Genes

HHEX
IRX3
SOX4
CDKAL1
FTO
IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20080751-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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