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Article

A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia

15 Apr 2021

Abstract excerpt

Significance Mutations in complement factor H (CFH) binding sites for heparan sulfate (HS) increase risk for age-related macular degeneration (AMD), but the roles of CFH and HS in disease pathogenesis remain unclear. Here, we find that a CFH homolog, HS modification, and the HS proteoglycan syndecan/SDN-1 have roles in maintaining cilia compartment boundaries in the sensory neurons of aging C. elegans adults. The...

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PMID: 33859044
DOI: 10.1073/pnas.2016698118

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