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Article

Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis.

Nature - 22 May 2003

Hwang Ho-Yon, Olson Sara K, Esko Jeffrey D, Horvitz H Robert

Abstract excerpt

Defects in glycosaminoglycan biosynthesis disrupt animal development and can cause human disease. So far much of the focus on glycosaminoglycans has been on heparan sulphate. Mutations in eight squashed vulva (sqv) genes in Caenorhabditis elegans cause defects in cytokinesis during embryogenesis and in vulval morphogenesis during postembryonic development. Seven of the eight sqv genes have been shown to control...

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PMID: 12761549
DOI: 10.1038/nature01634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis.PMID 12761549Read ↗

The Caenorhabditis elegans Genes sqv-2and sqv-6, Which Are Required for Vulval Morphogenesis, Encode Glycosaminoglycan Galactosyltransferase II and XylosyltransferaseSemantic proximity Read ↗

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sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination.Semantic proximity Read ↗

Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans.Semantic proximity Read ↗

Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans.Semantic proximity Read ↗

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Distal tip cell migration mutants of Caenorhabditis elegans are rescued by bioequivalent outputs from chondroitin and N-glycosylation pathways.Semantic proximity Read ↗

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Two Golgi-resident 3'-Phosphoadenosine 5'-phosphosulfate transporters play distinct roles in heparan sulfate modifications and embryonic and larval development in Caenorhabditis elegans.Semantic proximity Read ↗

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