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Article

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?

Journal of innate immunity - 1 Jan 2014

Langford-Smith Alex, Keenan Tiarnan D L, Clark Simon J, Bishop Paul N, Day Anthony J

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations and has been associated with complement dysregulation in the central retina. The Y402H polymorphism in the complement regulatory protein factor H (CFH) can confer a >5-fold increased risk of developing AMD and is present in approximately 30% of people of European descent. CFH, in conjunction with other factors, regulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 24335201
DOI: 10.1159/000356513
PMCID: PMC4086042

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?PMID 24335201Read ↗

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