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Article

Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 5 Aug 2014

Díaz-Balzac Carlos A, Lázaro-Peña María I, Tecle Eillen, Gomez Nathali, Bülow Hannes E

Abstract excerpt

The development of the nervous system is a complex process requiring the integration of numerous molecular cues to form functional circuits. Many cues are regulated by heparan sulfates, a class of linear glycosaminoglycan polysaccharides. These sugars contain distinct modification patterns that regulate protein-protein interactions. Misexpressing the homolog of KAL-1/anosmin-1, a neural cell adhesion molecule...

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Identifiers

PMID: 25098771
DOI: 10.1534/g3.114.012591
PMCID: PMC4199693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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