Article
Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction.
Human molecular genetics - 9 Jul 2021
Palmer Nicholette D, Kahali Bratati, Kuppa Annapurna, Chen Yanhua, Du Xiaomeng, Feitosa Mary F, Bielak Lawrence F, O'Connell Jeffrey R, Musani Solomon K, Guo Xiuqing, Smith Albert V, Ryan Kathleen A, Eirksdottir Gudny, Allison Matthew A, Bowden Donald W, Budoff Matthew J, Carr J Jeffrey, Chen Yii-Der I, Taylor Kent D, Correa Adolfo, Crudup Breland F, Halligan Brian, Yang Jian, Kardia Sharon L R, Launer Lenore J, Fu Yi-Ping, Mosley Thomas H, Norris Jill M, Terry James G, O'Donnell Christopher J, Rotter Jerome I, Wagenknecht Lynne E, Gudnason Vilmundur, Province Michael A, Peyser Patricia A, Speliotes Elizabeth K
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of exonic variation associated with NAFLD and correlated metabolic traits and diseases. An exome array meta-analysis was carried out...
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