Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer.

Journal of hepatology - 1 Dec 2024

Ahmed Altayeb, Cule Madeleine, Bell Jimmy D, Sattar Naveed, Yaghootkar Hanieh

Abstract excerpt

BACKGROUND & AIMS: The mechanisms underlying the association of steatotic liver disease with cardiovascular and cancer outcomes are poorly understood. We aimed to use MRI-derived measures of liver fat and genetics to investigate causal mechanisms that link higher liver fat to various health outcomes. METHODS: We conducted a genome-wide association study on 37,358 UK Biobank participants to identify genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Fatty Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Magnetic Resonance Imaging

Share to Mendelian Randomization Analysis

Share to Neoplasms

Share to United Kingdom

Source

Identifiers

PMID: 38960375
DOI: 10.1016/j.jhep.2024.06.030

Genes

IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer.PMID 38960375Read ↗

Machine learning enables new insights into clinical significance of and genetic contributions to liver fat accumulationSemantic proximity Read ↗

The role of liver fat in cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body compositionSemantic proximity Read ↗

Metabolic effects of risk alleles in <i>PNPLA3, TM6SF2, GCKR</i> and <i>LYPLAL1</i> inform about heterogeneity of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort.Semantic proximity Read ↗

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body compositionSemantic proximity Read ↗

Machine learning enables new insights into genetic contributions to liver fat accumulationSemantic proximity Read ↗

Unravelling genetic susceptibility and causal factors in liver health using MRI quantification of inflammation, fat and iron in the liver.Semantic proximity Read ↗

Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.Semantic proximity Read ↗

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene InteractionsSemantic proximity Read ↗

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content.Semantic proximity Read ↗

MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites.Semantic proximity Read ↗

Genetic risk of fatty liver disease and mortality in the general population: A Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.