Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease.

doi:10.1053/j.gastro.2020.12.023

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Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease.

Gastroenterology - 1 Apr 2021

Jamialahmadi Oveis, Mancina Rosellina Margherita, Ciociola Ester, Tavaglione Federica, Luukkonen Panu K, Baselli Guido, Malvestiti Francesco, Thuillier Dorothée, Raverdy Violeta, Männistö Ville, Pipitone Rosaria Maria, Pennisi Grazia, Prati Daniele, Spagnuolo Rocco, Petta Salvatore, Pihlajamäki Jussi, Pattou François, Yki-Järvinen Hannele, Valenti Luca, Romeo Stefano

Abstract excerpt

BACKGROUND & AIMS: Fatty liver disease (FLD) is a growing epidemic that is expected to be the leading cause of end-stage liver disease within the next decade. Both environmental and genetic factors contribute to the susceptibility of FLD. Several genetic variants contributing to FLD have been identified in exome-wide association studies. However, there is still a missing hereditability indicating that other...

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PMID: 33347879
DOI: 10.1053/j.gastro.2020.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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