Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.

doi:10.1016/j.xcrm.2021.100437

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Article

Electronic health record-based genome-wide meta-analysis provides insights on the genetic architecture of non-alcoholic fatty liver disease.

Cell reports. Medicine - 16 Nov 2021

Ghodsian Nooshin, Abner Erik, Emdin Connor A, Gobeil Émilie, Taba Nele, Haas Mary E, Perrot Nicolas, Manikpurage Hasanga D, Gagnon Éloi, Bourgault Jérôme, St-Amand Alexis, Couture Christian, Mitchell Patricia L, Bossé Yohan, Mathieu Patrick, Vohl Marie-Claude, Tchernof André, Thériault Sébastien, Khera Amit V, Esko Tõnu, Arsenault Benoit J

Abstract excerpt

Non-alcoholic fatty liver disease (NAFLD) is a complex disease linked to several chronic diseases. We aimed at identifying genetic variants associated with NAFLD and evaluating their functional consequences. We performed a genome-wide meta-analysis of 4 cohorts of electronic health record-documented NAFLD in participants of European ancestry (8,434 cases and 770,180 controls). We identify 5 potential...

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Identifiers

PMID: 34841290
DOI: 10.1016/j.xcrm.2021.100437
PMCID: PMC8606899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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