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Article

IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children.

Genes and immunity - 1 May 2021

Prokunina-Olsson Ludmila, Morrison Robert D, Obajemu Adeola, Mahamar Almahamoudou, Kim Sungduk, Attaher Oumar, Florez-Vargas Oscar, Sidibe Youssoufa, Onabajo Olusegun O, Hutchinson Amy A, Manning Michelle, Kwan Jennifer, Brand Nathan, Dicko Alassane, Fried Michal, Albert Paul S, Mbulaiteye Sam M, Duffy Patrick E

Abstract excerpt

Genetic polymorphisms within the IFNL3/IFNL4 genomic region, which encodes type III interferons, have been strongly associated with clearance of hepatitis C virus. We hypothesized that type III interferons might be important for the immune response to other pathogens as well. In a cohort of 914 Malian children, we genotyped functional variants IFNL4-rs368234815, IFNL4-rs117648444, and IFNL3-rs4803217 and analyzed...

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Identifiers

PMID: 33850301
DOI: 10.1038/s41435-021-00127-7
PMCID: PMC8042471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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